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pentobarbital will lower the extent or result of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.pentobarbital will lower the level or impact of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers is not encouragedpentobarbi